Progression of White Coat Hypertension to Sustained Hypertension After 10 Year Follow-up

Olga B. Paez, Pablo A. Puleio, Marta G. Gorocito, Miguel Visser, Miguel Schiavone, Claudio R. Majul



The long-term outcome of white coat hypertension (WCH) is still controversial despite the broad information currently available.


To evaluate the cumulative incidence of sustained hypertension (SH) among patients with white coat hypertension compared to normotensive patients 10 years after being included in the study.

Material and Methods

A total of 250 patients of both genders were prospectively included with the following office blood pressure (OBP) and 24-hour ambulatory blood pressure monitoring (ABPM) values:

WCH HS Normal BP

OBP (mm Hg)  140 and/or 90  140 and/or 90  140 and/or 90

ABPM (mm Hg)  135 and 85  135 and 85  135 and 85

The patients were divided into two groups: 129 patients with WCH and 121 normotensive patients, and were evaluated after 10 years of follow-up.

Glucose blood level, lipid profile and left ventricular mass index (LVMI) were measured.


Age, gender, smoking habits and glucose blood level were similar at baseline among normotensive patients and patients with white coat hypertension.

Yet, BMI, total cholesterol levels, lipid levels and LVMI were significantly greater in white-coat hypertensive patients. Sustained hypertension was developed by 48 patients with WCH and 21 normotensive patients. We found an independent association between WCH and SH at 10 years of follow-up [OR: 2.5 (95% CI 1.2-4.2)].


Progression to sustained hypertension was greater in patients with white coat hypertension compared to normotensive patients.


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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020