Preeclampsia is Preceded by Cardiovascular Function Abnormalities

Olga Paez, Pablo Puleio, Miguel Visser, Silvina Mazzeo, Leandro Antelo, Juan Alderete, Rubén Kevorkian, Claudio Majul

Abstract


Background: Preeclampsia (PE) is associated with changes in cardiovascular function (CVF), but whether these changes precedeand persist in the clinical phase of the disease is still unknown.Objectives: The aim of this study was to evaluate the differences in CVF at 22 weeks of pregnancy and one year after delivery inpatients who developed PE vs. those with normotension (N). The association between CVF at 22 weeks of pregnancy and the developmentof PE was also analyzed.Methods: A prospective study was conducted including 260 normotensive primiparous women. Routine laboratory tests, 24-hoururine protein and blood pressure (BP) were measured at 22 weeks and one year after delivery. Cardiac index (CI), systemic vascularresistance index (SVRI), and pulse wave velocity (PWV) were measured by impedance cardiography. The population was divided intothree groups according to the outcome during pregnancy: G1: PE, G2: gestational hypertension (GH) and G3: N. The results arepresented as mean ± SD, ANOVA and post hoc test, p <0.05.Results: Twelve patients evolved to PE, 18 to GH and 220 remained with N. In G1, CI was lower and BP, SVRI and PWV were higherthan in G3 at 22 weeks of pregnancy and one year after delivery. In G2, values were always intermediate between G1 and G3. PWVand SVRI measured at 22 weeks of pregnancy resulted predictors of PE.Conclusions: Patients who developed PE had different CVF in the early stage of pregnancy than those with normotension. The earlydiagnosis of those changes could predict PE and thus contribute to prevent its complications.

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