Left Ventricular Mass in Healthy Subjects of the City of Buenos Aires and its Correlation with Anthropometric Measurements

Araceli Segovia, Laura Brandani, Gisela Killinger, Leandro Zonis, Marcelo Risk, Julieta Paolini, Máximo Santos, Carlos Rodriguez Correa


Left ventricular hypertrophy is a risk predictor of cardiovascular events. The objectivesof this study were to establish reference values for left ventricular mass in anapparently healthy population of the Autonomous City of Buenos Aires, to analyzeits correlation with age and anthropometric variables and to define the best way toexpress the assessed data. Left ventricular mass was estimated using internationallysupported echocardiographic methods (American Society of Echocardiography/European Association of Echocardiography) and the adjusted Devereux equation.After applying strict exclusion criteria, 1898 subjects with mean age of 38 ± 11 years,48.89% of whom were male and 51.1% were female, were included in the study. Leftventricular mass was 155 ± 30 g for men (95th percentile 206 g) with normal distribution,and 112 ± 24 g for women (95th percentile 153 g) with non-normal distribution(p < 0.001 between genders). Values were comparable to those reported instudies using a similar methodology. Left ventricular mass index showed a moderatecorrelation with body surface area and weight, and significant differences betweengenders. As calculated variables exhibited heterogeneity in data distribution (normalor non-normal), the 95th percentile was assumed as the best way of expressingreference values. In conclusion, estimated reference values of left ventricular massin a healthy population correlated moderately with body surface area and weight.We propose the use of the 95th percentile to express the upper reference value of theassessed data.



Weidemann F, Niemann M, Ertl G, Stork S. The Different Faces of Echocardiographic Left Ventricular Hypertrophy: Clues to the Etiology. J Am Soc Echocardiogr 2010; 23:793-801.

Koren MJ, Devereux RB, Casale P, Savage DD, Laragh, JH. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 1991; 114: 345 – 352.

Levy D, Garrison R, Savage D, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined in left ventricular mass in the Framingham study. N Engl J Med 1990; 322: 1561 – 1566.

Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J 2001; 141:334-341.

Casale P, Devereux RB, Milner M, Zullo G, Harshfield GA, Pickering TG, et al. Value of Echocardiographic Measurement of Left Ventricular Mass in Predicting Cardiovascular Morbid Events in Hypertensive Men. Ann Intern Med 1986;105:173-l 78.

Devereux RB, Wachtell K, Gerdts E, Boman K, Nieminen MS, Papademetriou V, et al. Prognostic Significance of left Ventricular Mass Change During Treatment of Hypertension. JAMA 2004; 292: 2350 –2356.

Devereux RB, Palmieri V, Sharpe N, De Quattro V, Bella JN, De Simone G, et al. Effects of once – daily Angiotensin – Converting Enzyme inhibition and calcium channel blockade – based antihypertensive treatment regimens of left ventricular hypertrophy and diastolic filling in hypertension. The prospective randomized Enalapril study evaluating regression of ventricular enlargement (PRESERVE) Trial. Circulation 2001; 104: 1248 – 1254.

Casale PN, Devereux RB, Alonso DR, Campo E, Kligfield P. Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: validation with autopsy findings. Circulation1987; 75:565-572.

Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977; 55. 613 – 618.

Troy BL, Pombo J, Rackley CE. Measurement of left ventricular wall thickness and mass by echocardiography. Circulation 1972; 45:602-611.

Missouris CG, Forbat SM, Singer DRJ, Markandu ND, Underwood R, Mac Gregor GA. Echocardiography overestimates left ventricular mass: a comparative study with magnetic resonance imaging in patients with hypertension. J Hypertens 1996; 14:1005 – 1010.

Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450- 458.

Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography committee on standards, subcommittee on quantitation of two-dimensional echocardiograms. J Am Soc Echocardiogr 1989;2:358-67.

Wikstrand J. Calculation of left ventricular mass in man – a comment. J Hypertens 1997; 15:811–813.

DuBois D, DuBois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916; 17:863-71.

Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al.

Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18:1440-63.

Stephens, MA. EDF Statistics for Goodness of Fit and Some Comparisons. Journal of the American Statistical Association 1974; 347:730-737.

R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0, 2010, http://www.R-project.org/

Park S, Seo HS, Shim CY, Choi EY, Ko YG, Choi D, et al. Effect of Geometric Remodeling on Left Ventricular Longitudinal Contractile Reserve in Patients with Hypertension. J Am Soc of Echocardiogr 2008; 21: 246 – 250.

Kouzu H, Yuda S, Muranaka A, Doi T, Yamamoto H, Shimoshige S, et al. Left ventricular hypertrophy causes different changes in longitudinal, radial and circumferential mechanics in patients with hypertension: a two dimensional Speckle Tracking study. J Am Soc Echocardiogr 2011; 24: 192 – 199.

Ilercil I, O’ Grady MJ, BA, Roman MJ, Paranicas M, Lee E T, Welty TK, et al. Reference values for Echocardiographic measurements in urban and rural populations of differing ethnicity: The Strong Heart Study. J Am Soc Echocardiogr 2001;14: 601- 11.

Barbieri A, Bursi F, Mantovani F, Valenti C, Quaglia M, Berti E, et al. Prognostic impact of left ventricular mass severity according to the classification proposed by the American Society of Echocardiography/European Association of Echocardiography. J Am Soc Echocardiogr 2011; 24: 1383 – 91.

Devereux RB, Roman MJ, Simone G, O’Grady MG, Paranicas M, Yeh J, et al. Relations of left ventricular mass to demographic and hemodynamic variables in American Indians. Circulation 1997; 96: 1416 – 1423.

Shub C, Klein AL, Zachariah PK, Bailey KR, Tajik AJ. Determination of left ventricular mass by echocardiography in a normal population: effect of age and sex in addition to body size. Mayo Clin Proc 1994; 69: 205 – 211.

De Simone G, Devereux RB, Roman MJ, Ganau A, Chien S, Alderman MH, et al. Gender differences in left ventricular anatomy blood viscosity and volumen regulatory hormones in normal adults. Am J Cardiol 1991; 68: 1704 – 1708.

Ganau A, Saba PS, Roman MJ, de Simone G, Realdi G, Devereux RB.

Aging induces left ventricular concentric remodelling in normotensive subjects. J Hypertens 1995;13:1818 –22.

Wild PS, Sinning CR, Roth A, Wilde S, Schnabel RB, Lubos E, et al. Distribution and categorization of left ventricular measurements in the General Population. Results from the Population – based Gutenberg Heart Study. Circ Cardiovasc Imaging 2010; 3: 604 – 613.

Full Text


  • There are currently no refbacks.

Comments on this article

View all comments

Licencia Creative Commons
The documents published in this journal are under the licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.

Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020 www.sac.org.ar revista@sac.org.ar