Evaluation of a New Diagnostic Algorithm for Acute Coronary Syndrome Using High-Sensitivity Troponin T Assay

Juan Pablo Costabel, Diego Conde, Florencia Lambardi, Andrea Corrales Barboza, Augusto Lavalle Cobo, Martín Aragón, Marcelo Trivi


Introduction: Chest pain represents 5 to 10% of annual visits to emergency departments. Its diagnosis is sometimes difficult, with the added problem of inappropriate discharge of patients with acute coronary syndrome or unnecessary hospitalizations.This has led to the development of different algorithms for the evaluation of these patients.

Objective: The aim of this study was to validate, in terms of safety and length of hospital stay, a novel algorithm incorporatedin our center, which includes measurement of high-sensitivity troponin T in patients with suspected acute coronary syndrome.

Methods: The study included 528 consecutive patients attending the emergency department with suspected acute coronarysyndrome and evaluated according to the chest pain unit protocol. Clinical and laboratory variables and functional tests wereanalyzed. Follow-up at 30 days was performed in all the patients.Results: After observation, 90.7% of the patients were discharged and 1.25% presented a cardiovascular event during follow-up,represented by percutaneous coronary intervention and hospitalization due to acute coronary syndrome. The specificity of theglobal algorithm for the diagnosis of acute coronary syndrome was 97% with a negative predictive value of 99%. Emergencydepartment length of stay was 4.5 ± 2.5 hours for all the patients.

Conclusion: The novel algorithm incorporated in our center with measurement of high-sensitivity troponin T in patientswith suspected acute coronary syndrome has proved to be safe, as it prevents the discharge of patients with acute coronarysyndrome and at the same time reduces emergency department length of stay.

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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020 www.sac.org.ar revista@sac.org.ar