Pheochromocytomas and Paragangliomas: Experience of a Buenos Aires General Hospital

Silvina Santoro, Yandri Palma, Marta Barontini, Roberto Amicucci, Roberto Lamy, Susana Lupi


We report pheochromocytoma and paraganglioma case studies followed-up in the Hospital General de Agudos “José M. RamosMejía” Division of Endocrinology between 1994 and 2014. Twenty two patients were diagnosed and treated, 17 womenand 5 men. Sixteen patients presented with typical signs and symptoms, 2 had associated ischemic limb necrosis, and 4 werenormotensive (3 with incidentalomas and 1 with hyperglycemia and asthenia). Elevated urinary catecholamine and metanephrinelevels were found in all patients. Twelve patients exhibited unilateral adrenal disease (8 right and 4 left), 5 hadbilateral disease and 5 extra-adrenal disease Ten patients had familial syndromes. Eleven patients underwent laparoscopicsurgery and 11 required conversion to laparotomy due to tumor size or bleeding. During follow-up, biochemical recurrencewas observed in four patients, two with local recurrence, one with metastasis, and one with untraceable tumor). This reportof our institutional experience emphasizes the importance of a multidisciplinary approach to treat this disease.

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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020