Wall Thickness and Patterns of Fibrosis in Hypertrophic Cardiomyopathy Assessed by Cardiac Magnetic Resonance Imaging

Alejandro Deviggiano, Patricia Carrascosa, Macarena De Zan, Carlos Capuñay, Héctor Deschle, Gastón A. Rodríguez Granillo

Abstract


Background: Hypertrophic cardiomyopathy is the most common genetic cardiac disease and the main cause of sudden death in theyoung. Cardiac magnetic resonance imaging can characterize the different forms of hypertrophic cardiomyopathy and detect myocardialfibrosis by late gadolinium enhancement.Objectives: The aim of this study was to characterize the regional distribution of left ventricular wall thickness and its relationwith myocardial fibrosis, and also quantify the percentage and determine the different patterns of left gadolinium enhancement inpatients with hypertrophic cardiomyopathy evaluated with cardiac magnetic resonance imaging.Methods: This observational study evaluated patients with hypertrophic cardiomyopathy undergoing contrast-enhanced cardiacmagnetic resonance imaging. The results were compared with a group of control patients. Hypertrophic cardiomyopathy morphologywas evaluated and the percentage of late gadolinium enhancement was determined.Results: Maximum wall thickness was observed in the mid inferoseptal (16.8±5.3 mm), basal anteroseptal (16.5±6.2 mm), and midanteroseptal segments (15.4±6.2 mm). Thirty patients (71%) with hypertrophic cardiomyopathy presented late gadolinium enhancementin 141/672 (21%) of the segments evaluated. Late gadolinium enhancement was predominantly intramyocardial (n=103,73%). A significant association was found between the percentage of late gadolinium enhancement in the left ventricle and maximummyocardial wall thickness.Conclusions: Maximum wall thickness was more frequently observed in the basal and mid septal segments. Two-thirds of thesepatients presented late gadolinium enhancement which was associated with maximum wall thickness

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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020 www.sac.org.ar revista@sac.org.ar