Blood Pressure Pattern during Sleep-Wake Cycle in Subjects with High Prevalence of Metabolic Syndrome

Ulises Leal, Milagros Espinosa, Nelida Ruiz, Dalis Padilla, Jotshari Ochoa, Graciela Nicita


The reduction of nocturnal drop in blood pressure correlates

with a higher risk of cardiovascular complications.

In addition, the metabolic syndrome (MS) significantly

increases cardiovascular risk. We conducted a descriptive,

cross-sectional study to evaluate the pattern of nocturnal

drop in blood pressure and other parameters provided by

24-hour ambulatory blood pressure monitoring (ABPM),

such as mean daytime and nighttime systolic, diastolic and

pulse pressures in subjects with MS, and to determine the

relation with the components of this syndrome. A total of

125 patients were included, with ABPM reproducibility

pattern. Glycemia, HDL-cholesterol, triglycerides, office

blood pressure and abdominal circumference were determined.

The presence of MS was defined using the ATP III

criteria. The global prevalence of hypertension, MS and

non-dipper pattern was 43%, 56% and 44%, respectively.

Blood pressure values and the percentage of patients with

non-dipper pattern were higher in patients with more

components of the metabolic syndrome. The abdominal

circumference was the only parameter that predicted the

non-dipper pattern. Subjects with MS showed a significant

increase in the different blood pressure parameters evaluated

by ABPM and a higher prevalence of the non-dipper


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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020