Approach on the Use of Statins in a Sample of Doctors from Argentina. The COFEMA Study

Andres Rosende, Cristian Caniggia, Jorge Casuscelli, Micaela Mirada, Daniel Comtesse, Adrián Charask, Heraldo D´Imperio, Luis Cámera, Pascual Valdez, Carlos Tajer


Background: Available information on the use of statins is very abundant and complex, and in recent years, different recommendations have been published in local and international guidelines. Since the evidence with statins has generated variations in their indication, it is interesting to know the degree of guideline acceptance and the approach of our medical community regarding their use. Objective: The aim of this study was to identify physician approach on the use of statins in Argentina. Methods: A 16-item survey was carried out to investigate the degree of agreement with different statin indications and usual dosage. A descriptive analysis was performed and comparisons by specialty and age group were carried out. Results: The median age of the 598 respondents was 48 years. Most physicians agreed to indicate high doses of statins in secondary prevention and in diabetic patients. When LDL-C >190 mg/dL was the only risk criterion, 50% of respondents did not approve the indication. In primary prevention, one in three physicians agreed to discontinue treatment after normalizing cholesterol levels. In two controversial conditions, such as chronic coronary artery disease in patients on dialysis and advanced coronary heart failure, the indication of statins was high. Most respondents monitor adverse effects with hepatograms and CPK measurements in asymptomatic patients.

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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020