Use of the Proportional Entropy Method to Assess Electrocardiographic Records

Gerardo Nau, Nicolás Lalor, Juan P. Costabel, Gustavo Pedernera, Pablo Morales, Alfonsina Candiello, Marcelo Trivi, Pablo Spaletra, Fernando Cura, Mariano Benzadón


Background: A new diagnostic methodology developed in the context of dynamical system theory has enabled the assessment of electrocardiographic registries, achieving objective and reproducible diagnoses. Objective: The purpose of this study was to confirm the clinical applicability of this methodology based on the entropy probability and proportions of the attractor, using a blinded study compared with the gold standard. Methods: A total of 650 electrocardiographic registries were analyzed: 150 normal and 500 with different diseases. Numerical attractors were generated from 18-hour registries of heart rate values and the probability, entropy and entropy proportions of each attractor were calculated. The physical-mathematical diagnosis was established and the clinical applicability and reproducibility of the mathematical methodology was compared with the conventional clinical diagnosis, calculating sensitivity, specificity and kappa coefficient. Results: One hundred percent sensitivity and specificity and a kappa coefficient of 1 with regard to the conventional clinical diagnosis confirmed the clinical applicability of the postulated method. Conclusion: Use of this methodology allowed a quantitative differentiation between normal and abnormal cardiac dynamic states. This evidences self-organization of the geometric dynamic attractor, constituting a method of diagnostic aid applicable to clinical practice.


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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020