Plasma VEGF Level Changes with Exercise in Patients with Chronic Coronary Artery Disease

Juan Gagliardi, Neiva Maciel, José Luis Castellano, Verónica Miksztowicz, Gabriela Berg, Ricardo J. Gelpi


The aim of this study was to assess the effect of acute and programmed physical exercise on plasma VEGF levels in chronicstable coronary artery disease patients. Following baseline evaluation, 21 patients <75 years underwent a stress myocardialperfusion scan (acute), and were then randomly assigned to perform programmed rehabilitation exercise or continue withtheir normal therapy. VEGF assessed by SPECT imaging significantly decreased after stress ergometry (from 49.59±6.06 to31.83±5.62 pg/ml; p=0.021). At one month, it increased (70.90±14.44 pg/ml) though not significantly with respect to baselinevalues (p=0.1) and significantly with respect to immediate post-stress values (p<0.01). No significant changes were observedin VEGF at 3 months or when results were compared according to the presence of ischemia or programmed exercise.Acute exercise induced a significant reduction in VEGF values, without differences between programmed exercise and thecontrol group.

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Revista argentina de cardiología. ISSN en línea 1850-3748. Argentine journal of cardiology (English ed. Online ISSN 2314-2286) Sociedad Argentina de Cardiología. Azcuénaga 980 (C1115AAD),Ciudad Autónoma de Buenos Aires, República Argentina. Tel. (54 11) 4961-6027/8/9 Fax: 4961-6020